Application
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with FDPS antibody (Center ), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.| Product Name | FDPS Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | IHC |
| IHC:1:10~50 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | FPS, KIAA1293 |
|---|---|
| Alternative Names | FDPS FPS KIAA1293 Farnesyl pyrophosphate synthase (2E 6E)-farnesyl diphosphate synthase Dimethylallyltranstransferase Farnesyl diphosphate synthase Geranyltranstransferase |
| Molecular Weight(MW) | 48275 Da |
| Function | Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate |
| Tissue Specificity | This FDPS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 338~453 amino acids from the center region of human FDPS. |
| Cellular Localization | Cytoplasm. |
| Entrez Gene | 2224 |
|---|
Application
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with FDPS antibody (Center ), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.| Application Notes | IHC:1:10~50 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
