Application
FERMT1 Antibody (Center) western blot analysis in Hela,HepG2 cell line lysates (35ug/lane).This demonstrates the FERMT1 antibody detected the FERMT1 protein (arrow).Application
Western blot analysis of FERMT1 Antibody (Center) in mouse stomach tissue lysates (35ug/lane). FERMT1 (arrow) was detected using the purified Pab| Product Name | FERMT1 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | C20orf42, KIND1, URP1 |
|---|---|
| Alternative Names | FERMT1 C20orf42 KIND1 URP1 Fermitin family homolog 1 Kindlerin Kindlin syndrome protein Kindlin-1 Unc-112-related protein 1 |
| Molecular Weight(MW) | 77437 Da |
| Function | Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression |
| Tissue Specificity | Expressed in brain, skeletal muscle, kidney, colon, adrenal gland, prostate, and placenta. Weakly or not expressed in heart, thymus, spleen, liver, small intestine, bone marrow, lung and peripheral blood leukocytes. Overexpressed in some colon and lung tumors. In skin, it is localized within the epidermis and particularly in basal keratocytes. Not detected in epidermal melanocytes and dermal fibroblasts |
| Cellular Localization | Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Constituent of focal adhesions. Localized at the basal aspect of skin keratinocytes, close to the cell membrane. Colocalizes with filamentous actin Upon TGFB1 treatment, it localizes to membrane ruffles |
| Entrez Gene | 55612 |
|---|
Application
FERMT1 Antibody (Center) western blot analysis in Hela,HepG2 cell line lysates (35ug/lane).This demonstrates the FERMT1 antibody detected the FERMT1 protein (arrow).
Application
Western blot analysis of FERMT1 Antibody (Center) in mouse stomach tissue lysates (35ug/lane). FERMT1 (arrow) was detected using the purified Pab| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
