Application
Figure 1: Western blot analysis using anti-FES monoclonal antiobdy against truncated FES recombinant protein.Application
Figure 2: Immunohistochemical analysis of paraffin-embedded human cerebrum tumor(A), endothelium of vessel(B), lymphocyte of thymus(C), showing cytoplasmic localization using anti-FES antibody with DAB staining.| Product Name | FES Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 2E3G3, 2G9G1 |
| Host Species | Mouse |
| Tested Applications | WBIHC |
| WB:1:500 - 2000. |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | FPS |
|---|---|
| Alternative Names | FPS |
| Molecular Weight(MW) | 93497 Da |
| Function | Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down- stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28 |
| Tissue Specificity | Widely expressed. Detected in adult colon epithelium |
| Cellular Localization | Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasmic vesicle. Golgi apparatus. Cell junction, focal adhesion. Note=Distributed throughout the cytosol when the kinase is not activated. Association with microtubules requires activation of the kinase activity. Shuttles between focal adhesions and cell-cell contacts in epithelial cells. Recruited to the lateral cell membrane in polarized epithelial cells by interaction with phosphorylated EZR. Detected at tubular membrane structures in the cytoplasm and at the cell periphery |
| Entrez Gene | 2242 |
|---|---|
| Nucleotide Accession | NP_001996.1 |
Application
Figure 1: Western blot analysis using anti-FES monoclonal antiobdy against truncated FES recombinant protein.
Application
Figure 2: Immunohistochemical analysis of paraffin-embedded human cerebrum tumor(A), endothelium of vessel(B), lymphocyte of thymus(C), showing cytoplasmic localization using anti-FES antibody with DAB staining.| Application Notes | WB:1:500 - 2000. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified recombinant fragment of FES expressed in E. Coli. |
