Application
FGD2 Antibody (C-term) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the FGD2 antibody detected the FGD2 protein (arrow).Application
FGD2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of FGD2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | FGD2 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | ZFYVE4 |
|---|---|
| Alternative Names | FGD2 ZFYVE4 FYVE RhoGEF and PH domain-containing protein 2 Zinc finger FYVE domain-containing protein 4 |
| Molecular Weight(MW) | 74892 Da |
| Function | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5- bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4- monophosphate and phosphatidylinositol 3-monophosphate (By similarity) |
| Tissue Specificity | This FGD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 507-537 amino acids from the C-terminal region of human FGD2. |
| Cellular Localization | Cytoplasm, cytoskeleton (Probable). Cytoplasm (By similarity). Nucleus (By similarity). Early endosome (By similarity). Early endosome membrane (By similarity). Cell projection, ruffle membrane (By similarity). Note=Recruitment to the endosome and ruffle membrane requires the presence of phosphoinositides (By similarity) |
| Entrez Gene | 221472 |
|---|---|
| Nucleotide Accession | NP_775829.2 |
Application
FGD2 Antibody (C-term) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the FGD2 antibody detected the FGD2 protein (arrow).
Application
FGD2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of FGD2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
