Application
FIGLA Antibody (Center) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the FIGLA antibody detected the FIGLA protein (arrow).| Product Name | FIGLA Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | BHLHC8 |
|---|---|
| Alternative Names | FIGLA BHLHC8 Factor in the germline alpha Class C basic helix-loop-helix protein 8 Folliculogenesis-specific basic helix-loop-helix protein Transcription factor FIGa |
| Molecular Weight(MW) | 24123 Da |
| Function | Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E- box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters |
| Tissue Specificity | Germ cells. Expressed in the fetal ovary, but not by a range of other tissues. Expression increases across mid- gestation, rising some 40-fold by the time of primordial follicle formation |
| Cellular Localization | Nucleus (Probable). |
| Entrez Gene | 344018 |
|---|---|
| Nucleotide Accession | NP_001004311.2 |
Application
FIGLA Antibody (Center) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the FIGLA antibody detected the FIGLA protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
