Application
Western blot analysis of FLCN Antibody (C-term) Pab pre-incubated without(lane 1) and with(lane 2) blocking peptide in K562 cell line lysate. FLCN (arrow) was detected using the purified Pab (1:250 dilution).Application
FLCN Antibody (C-term) flow cytometric analysis of k562 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.Application
FLCN Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the FLCN Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | FLCN Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBFCIHC |
| WB:1:100~500 FC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | BHD |
|---|---|
| Alternative Names | FLCN BHD Folliculin BHD skin lesion fibrofolliculoma protein Birt-Hogg-Dube syndrome protein |
| Molecular Weight(MW) | 64473 Da |
| Function | May play a role in the pathogenesis of an uncommon form of kidney cancer through its association with an inherited disorder of the hair follicle (fibrofolliculomas). May be a tumor suppressor. May be involved in colorectal tumorigenesis. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 |
| Tissue Specificity | Expressed in most tissues tested, including skin, lung, kidney, heart, testis and stomach |
| Cellular Localization | Cytoplasm. Nucleus. Note=Mainly localized in the nucleus. Co-localizes with FNIP1 and FNIP2 in the cytoplasm |
| Entrez Gene | 201163 |
|---|
Application
Western blot analysis of FLCN Antibody (C-term) Pab pre-incubated without(lane 1) and with(lane 2) blocking peptide in K562 cell line lysate. FLCN (arrow) was detected using the purified Pab (1:250 dilution).
Application
FLCN Antibody (C-term) flow cytometric analysis of k562 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Application
FLCN Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the FLCN Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 FC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
