Application
Western blot analysis of FLCN Antibody (Center) in CEM cell line lysates (35ug/lane). FLCN (arrow) was detected using the purified Pab.Application
Formalin-fixed and paraffin-embedded human lung carcinoma reacted with FLCN Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.| Product Name | FLCN Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | FLCN; BHD; Folliculin; BHD skin lesion fibrofolliculoma protein; Birt-Hogg-Dube syndrome protein |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | BHD |
|---|---|
| Alternative Names | FLCN BHD Folliculin BHD skin lesion fibrofolliculoma protein Birt-Hogg-Dube syndrome protein |
| Molecular Weight(MW) | 64473 Da |
| Function | May play a role in the pathogenesis of an uncommon form of kidney cancer through its association with an inherited disorder of the hair follicle (fibrofolliculomas). May be a tumor suppressor. May be involved in colorectal tumorigenesis. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 |
| Tissue Specificity | Expressed in most tissues tested, including skin, lung, kidney, heart, testis and stomach |
| Cellular Localization | Cytoplasm. Nucleus. Note=Mainly localized in the nucleus. Co-localizes with FNIP1 and FNIP2 in the cytoplasm |
| Entrez Gene | 201163 |
|---|
Application
Western blot analysis of FLCN Antibody (Center) in CEM cell line lysates (35ug/lane). FLCN (arrow) was detected using the purified Pab.
Application
Formalin-fixed and paraffin-embedded human lung carcinoma reacted with FLCN Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
