Application
FKRP Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the FKRP antibody detected the FKRP protein (arrow).| Product Name | FKRP Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | FKRP Fukutin-related protein |
|---|---|
| Molecular Weight(MW) | 54568 Da |
| Function | Could be a transferase involved in the modification of glycan moieties of alpha-dystroglycan (DAG1) |
| Tissue Specificity | Expressed predominantly in skeletal muscle, placenta, and heart and relatively weakly in brain, lung, liver kidney and pancreas |
| Cellular Localization | Golgi apparatus membrane; Single-pass type II membrane protein. Secreted. Cell membrane, sarcolemma (By similarity). Rough endoplasmic reticulum. Note=According to some studies the N-terminal hydrophobic domain is cleaved after translocation to the Golgi apparatus and the protein is secreted Localization at the cell membrane may require the presence of dystroglycan. At the Golgi apparatus localizes to the middle-to- trans-cisternae, as assessed by MG160 colocalization. Detected in rough endoplasmic reticulum in myocytes. In general, mutants associated with severe clinical phenotypes are retained within the endoplasmic reticulum |
| Entrez Gene | 79147 |
|---|---|
| Nucleotide Accession | NP_077277.1 NP_001034974.1 |
Application
FKRP Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the FKRP antibody detected the FKRP protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
