Application
Western blot analysis of FOXA3 Antibody (C-term) in HL-60 cell line lysates (35ug/lane). FOXA3 (arrow) was detected using the purified Pab.| Product Name | FOXA3 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | FOXA3; HNF3G; TCF3G; Hepatocyte nuclear factor 3-gamma; Fork head-related protein FKH H3; Forkhead box protein A3; Transcription factor 3G |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:50~100 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | HNF3G TCF3G |
|---|---|
| Alternative Names | FOXA3 HNF3G TCF3G Hepatocyte nuclear factor 3-gamma Fork head-related protein FKH H3 Forkhead box protein A3 Transcription factor 3G |
| Molecular Weight(MW) | 37140 Da |
| Function | Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis |
| Tissue Specificity | Expressed in erythroleukemia and hepatoma cell lines and in liver and pancreas. Not expressed in any other cell lines or tissues examined |
| Cellular Localization | Nucleus. |
| Entrez Gene | 3171 |
|---|
Application
Western blot analysis of FOXA3 Antibody (C-term) in HL-60 cell line lysates (35ug/lane). FOXA3 (arrow) was detected using the purified Pab.| Application Notes | WB:1:50~100 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
