Application
FOXO3 Antibody(Cat. #AM2130b) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the FOXO3 antibody detected the FOXO3 protein (arrow).| Product Name | FOXO3 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | FOXO3; FKHRL1; FOXO3A; Forkhead box protein O3; AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1 |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 543CT1.3.1 |
| Host Species | Mouse |
| Tested Applications | WB |
| WB:1:100 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | FKHRL1 FOXO3A |
|---|---|
| Alternative Names | FOXO3 FKHRL1 FOXO3A Forkhead box protein O3 AF6q21 protein Forkhead in rhabdomyosarcoma-like 1 |
| Molecular Weight(MW) | 71277 Da |
| Function | Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post- transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation |
| Tissue Specificity | Ubiquitous. |
| Cellular Localization | Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus upon oxidative stress and in the absence of survival factors |
| Entrez Gene | 2309 |
|---|---|
| Nucleotide Accession | NP_001446.1 |
Application
FOXO3 Antibody(Cat. #AM2130b) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the FOXO3 antibody detected the FOXO3 protein (arrow).| Application Notes | WB:1:100 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
