Application
FXN Antibody (N-term) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the FXN antibody detected the FXN protein (arrow).| Product Name | FXN Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | FXN; FRDA; X25; Frataxin, mitochondrial; Friedreich ataxia protein; Frataxin intermediate form; Frataxin(56-210); m56-FXN; Frataxin(78-210); d-FXN; m78-FXN; Frataxin mature form; Frataxin(81-210); m81-FXN |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | FRDA X25 |
|---|---|
| Alternative Names | FXN FRDA X25 Frataxin mitochondrial Friedreich ataxia protein Frataxin intermediate form Frataxin(56-210) m56-FXN Frataxin(78-210) d-FXN m78-FXN Frataxin mature form Frataxin(81-210) m81-FXN |
| Molecular Weight(MW) | 23135 Da |
| Function | Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. Modulates the RNA-binding activity of ACO1 |
| Tissue Specificity | Expressed in the heart, peripheral blood lymphocytes and dermal fibroblasts |
| Cellular Localization | Cytoplasm. Mitochondrion. Note=PubMed:18725397 reports localization exclusively in mitochondria |
| Entrez Gene | 2395 |
|---|---|
| Nucleotide Accession | NP_000135.2 |
Application
FXN Antibody (N-term) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the FXN antibody detected the FXN protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
