Application
GAR1 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the GAR1 antibody detected the GAR1 protein (arrow).| Product Name | GAR1 (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | NOLA1 |
|---|---|
| Alternative Names | GAR1 NOLA1 H/ACA ribonucleoprotein complex subunit 1 Nucleolar protein family A member 1 snoRNP protein GAR1 |
| Molecular Weight(MW) | 22348 Da |
| Function | Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme |
| Tissue Specificity | This GAR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-114 amino acids from the Central region of human GAR1. |
| Cellular Localization | Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies) |
| Entrez Gene | 54433 |
|---|---|
| Nucleotide Accession | NP_127460.1 |
Application
GAR1 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the GAR1 antibody detected the GAR1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
