Application
GCH1 Antibody (N-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the GCH1 antibody detected the GCH1 protein (arrow).Application
GCH1 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the GCH1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | GCH1 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | DYT5, GCH |
|---|---|
| Alternative Names | GCH1 DYT5 GCH GTP cyclohydrolase 1 GTP cyclohydrolase I |
| Molecular Weight(MW) | 27903 Da |
| Function | Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown |
| Tissue Specificity | In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level) |
| Cellular Localization | Cytoplasm. Nucleus. |
| Entrez Gene | 2643 |
|---|---|
| Nucleotide Accession | NP_000152.1 NP_001019195.1 NP_001019242.1 NP_001019241.1 |
Application
GCH1 Antibody (N-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the GCH1 antibody detected the GCH1 protein (arrow).
Application
GCH1 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the GCH1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
