Application
GHR Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the GHR antibody detected the GHR protein (arrow).Application
Confocal immunofluorescent analysis of GHR Antibody (N-term)(Cat#AP16661a) with MDA-MB231 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).| Product Name | GHR Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIF |
| WB:1:100~500 IF |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | GHR Growth hormone receptor Somatotropin receptor Growth hormone-binding protein Serum-binding protein |
|---|---|
| Molecular Weight(MW) | 71500 Da |
| Function | Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity) Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling |
| Tissue Specificity | Expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform 1 expression in placenta is predominant in chorion and decidua. Isoform 4 is highly expressed in placental villi. Isoform 2 is expressed in lung, stomach and muscle. Low levels in liver |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. Note=On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway (By similarity) Growth hormone-binding protein: Secreted. Note=Complexed to a substantial fraction of circulating GH (By similarity) |
| Entrez Gene | 2690 |
|---|---|
| Nucleotide Accession | NP_000154.1 |
Application
GHR Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the GHR antibody detected the GHR protein (arrow).
Application
Confocal immunofluorescent analysis of GHR Antibody (N-term)(Cat#AP16661a) with MDA-MB231 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).| Application Notes | WB:1:100~500 IF |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
