Application
GLIS2 Antibody (Center) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the GLIS2 antibody detected the GLIS2 protein (arrow).| Product Name | GLIS2 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | GLIS2; NKL; Zinc finger protein GLIS2; GLI-similar 2; Neuronal Krueppel-like protein |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | NKL |
|---|---|
| Alternative Names | GLIS2 NKL Zinc finger protein GLIS2 GLI-similar 2 Neuronal Krueppel-like protein |
| Molecular Weight(MW) | 55689 Da |
| Function | Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity) Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity) |
| Tissue Specificity | Expressed at high levels in kidney and at low levels in heart, lung and placenta. Expressed in colon |
| Cellular Localization | Nucleus speckle (By similarity). Cytoplasm (By similarity) |
| Entrez Gene | 84662 |
|---|---|
| Nucleotide Accession | NP_115964.2 |
Application
GLIS2 Antibody (Center) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the GLIS2 antibody detected the GLIS2 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
