Application
Fig 1. Western blot analysis on (A) HepG2 and (B) human fetal liver (C) mouse kidney (D) mouse spleen lysates using anti-Glucagon RabMAb (Cat. #AJ1321a).Application
Fig 2. Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-Glucagon RabMAb (Cat. #AJ1321a).| Product Name | Glucagon Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Monoclonal |
|---|---|
| Clone Number | EP3070 |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:1000~10000 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Molecular Weight(MW) | 20909 Da |
|---|---|
| Function | Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life |
| Tissue Specificity | Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP-1 and GLP-2 are also secreted in selected neurons in the brain |
| Cellular Localization | Secreted. |
| Entrez Gene | 2641 |
|---|
Application
Fig 1. Western blot analysis on (A) HepG2 and (B) human fetal liver (C) mouse kidney (D) mouse spleen lysates using anti-Glucagon RabMAb (Cat. #AJ1321a).
Application
Fig 2. Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-Glucagon RabMAb (Cat. #AJ1321a).| Application Notes | WB:1:1000~10000 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
