Application
A. Western blot analysis on human brain lysate using anti-GluR2/3 RabMAb (Cat. #AJ1323b).Application
B. Immunohistochemical staining of paraffin-embedded human brain using anti-GluR2/3 RabMAb (Cat. #AJ1323b).| Product Name | GluR2/3 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | GRIA2, GLUR2, Glutamate receptor 2, GluR-B;GluR-K2;Glutamate receptor ionotropic, AMPA 2;AMPA-selective glutamate receptor 2 |
| Clonality | Monoclonal |
|---|---|
| Clone Number | EP929Y |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:20000~50000 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | GLUR2 |
|---|---|
| Alternative Names | GRIA2 GLUR2 Glutamate receptor 2 GluR-B GluR-K2 Glutamate receptor ionotropic AMPA 2 AMPA-selective glutamate receptor 2 |
| Molecular Weight(MW) | 98821 Da |
| Function | Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate |
| Tissue Specificity | A synthetic phospho-peptide corresponding to residues surrounding Ser880/891 of human GluR2/3 was used as immunogen. The antibody detects both GluR2/3 phosphorylated on Serine 880/891 of the mature human, and also unphosphorylated Glur-2/3. |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression (By similarity) |
| Entrez Gene | 2891 |
|---|
Application
A. Western blot analysis on human brain lysate using anti-GluR2/3 RabMAb (Cat. #AJ1323b).
Application
B. Immunohistochemical staining of paraffin-embedded human brain using anti-GluR2/3 RabMAb (Cat. #AJ1323b).| Application Notes | WB:1:20000~50000 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
