Application
GPRC6A Antibody (Center) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the GPRC6A antibody detected the GPRC6A protein (arrow).| Product Name | GPRC6A Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | GPRC6A; G-protein coupled receptor family C group 6 member A; G-protein coupled receptor GPCR33 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | GPRC6A G-protein coupled receptor family C group 6 member A G-protein coupled receptor GPCR33 |
|---|---|
| Molecular Weight(MW) | 104753 Da |
| Function | Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalents ions and its responsiveness to anabolic steroids |
| Tissue Specificity | Isoform 1 is expressed at high level in brain, skeletal muscle, testis, bone, calvaria, osteoblasts and leukocytes. Expressed at intermediate level in liver, heart, kidney and spleen. Expressed at low level in lung, pancreas, placenta and ovary. Not detected in thymus, prostate, small intestine, tongue and colon. Isoform 1 and isoform 2 are expressed in kidney at the same level. Isoform 2 is expressed at lower level than isoform 1 in the other tissues |
| Cellular Localization | Cell membrane; Multi-pass membrane protein (By similarity) |
| Entrez Gene | 222545 |
|---|---|
| Nucleotide Accession | NP_683766.2 |
Application
GPRC6A Antibody (Center) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the GPRC6A antibody detected the GPRC6A protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
