Application
Western blot analysis of GRB7 Antibody (Center) in mouse brain tissue lysates (35ug/lane). GRB7 (arrow) was detected using the purified Pab.| Product Name | GRB7 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | GRB7; Growth factor receptor-bound protein 7; B47; Epidermal growth factor receptor GRB-7; GRB7 adapter protein |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | GRB7 Growth factor receptor-bound protein 7 B47 Epidermal growth factor receptor GRB-7 GRB7 adapter protein |
|---|---|
| Molecular Weight(MW) | 59681 Da |
| Function | Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity) |
| Tissue Specificity | This GRB7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 297~326 amino acids from the Central region of human GRB7. |
| Cellular Localization | Cytoplasm. Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasmic granule (By similarity). Cell projection Note=Predominantly cytoplasmic. Detected in stress granules, where mRNA is stored under stress conditions (By similarity) |
| Entrez Gene | 2886 |
|---|
Application
Western blot analysis of GRB7 Antibody (Center) in mouse brain tissue lysates (35ug/lane). GRB7 (arrow) was detected using the purified Pab.| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
