Application
Western blot analysis of anti-HAND2 Antibody (C-term) in NCI-H460 cell line lysates (35ug/lane). HAND2(arrow) was detected using the purified Pab.| Product Name | HAND2 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | HAND2; BHLHA26; DHAND; Heart- and neural crest derivatives-expressed protein 2; Class A basic helix-loop-helix protein 26; Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | BHLHA26 DHAND |
|---|---|
| Alternative Names | HAND2 BHLHA26 DHAND Heart- and neural crest derivatives-expressed protein 2 Class A basic helix-loop-helix protein 26 Deciduum heart autonomic nervous system and neural crest derivatives-expressed protein 2 |
| Molecular Weight(MW) | 23666 Da |
| Function | Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity) |
| Tissue Specificity | Heart. |
| Cellular Localization | Nucleus (By similarity). |
Application
Western blot analysis of anti-HAND2 Antibody (C-term) in NCI-H460 cell line lysates (35ug/lane). HAND2(arrow) was detected using the purified Pab.| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
