Application
HBEGF Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the HBEGF antibody detected the HBEGF protein (arrow).| Product Name | HBEGF Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | HBEGF; DTR; DTS; HEGFL; Proheparin-binding EGF-like growth factor; Heparin-binding EGF-like growth factor; Diphtheria toxin receptor |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | DTR DTS HEGFL |
|---|---|
| Alternative Names | HBEGF DTR DTS HEGFL Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor Diphtheria toxin receptor |
| Molecular Weight(MW) | 23067 Da |
| Function | Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF Also acts as a diphtheria toxin receptor |
| Tissue Specificity | This HBEGF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-96 amino acids from the Central region of human HBEGF. |
| Cellular Localization | Heparin-binding EGF-like growth factor: Secreted, extracellular space. Note=Mature HB-EGF is released into the extracellular space and probably binds to a receptor |
| Entrez Gene | 1839 |
|---|---|
| Nucleotide Accession | NP_001936.1 |
Application
HBEGF Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the HBEGF antibody detected the HBEGF protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
