Application
HCN1 Antibody (C-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the HCN1 antibody detected the HCN1 protein (arrow).Application
HCN1 Antibody (C-term) (AP14228b)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of HCN1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | HCN1 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | HCN1; BCNG1; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1; Brain cyclic nucleotide-gated channel 1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | BCNG1 |
|---|---|
| Alternative Names | HCN1 BCNG1 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 Brain cyclic nucleotide-gated channel 1 |
| Molecular Weight(MW) | 98796 Da |
| Function | Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. May mediate responses to sour stimuli |
| Tissue Specificity | Detected in brain, in particular in amygdala and hippocampus, while expression in caudate nucleus, corpus callosum, substantia nigra, subthalamic nucleus and thalamus is very low or not detectable. Detected at very low levels in muscle and pancreas |
| Cellular Localization | Membrane; Multi-pass membrane protein. |
| Entrez Gene | 348980 |
|---|---|
| Nucleotide Accession | NP_066550.2 |
Application
HCN1 Antibody (C-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the HCN1 antibody detected the HCN1 protein (arrow).
Application
HCN1 Antibody (C-term) (AP14228b)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of HCN1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
