Application
Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with HDAC6 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.Application
The anti-HDAC6 Pab is used in Western blot to detect HDAC6 in mouse kidney tissue lysate.| Product Name | HDAC6 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | HDAC6; KIAA0901; Histone deacetylase 6 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| IHC:1:10~50 WB |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA0901 |
|---|---|
| Alternative Names | HDAC6 KIAA0901 Histone deacetylase 6 |
| Molecular Weight(MW) | 131419 Da |
| Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity) Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin |
| Tissue Specificity | This HDAC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human HDAC6. |
| Cellular Localization | Nucleus. Cytoplasm. Note=It is mainly cytoplasmic, where it is associated with microtubules |
Application
Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with HDAC6 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Application
The anti-HDAC6 Pab is used in Western blot to detect HDAC6 in mouse kidney tissue lysate.| Application Notes | IHC:1:10~50 WB |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
