Application
Western blot analysis of HFE2 Antibody (Center) in mouse heart tissue lysates (35ug/lane). HFE2 (arrow) was detected using the purified Pab.Application
HFE2 Antibody (Center) IHC analysis in formalin fixed and paraffin embedded skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the HFE2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | HFE2 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | HFE2; HJV; RGMC; Hemojuvelin; Hemochromatosis type 2 protein; RGM domain family member C |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | HJV RGMC |
|---|---|
| Alternative Names | HFE2 HJV RGMC Hemojuvelin Hemochromatosis type 2 protein RGM domain family member C |
| Molecular Weight(MW) | 45080 Da |
| Function | Member of the repulsive guidance molecule (RGM) family. Involved in iron metabolism. Acts as a bone morphogenetic protein (BMP) coreceptor (By similarity). Enhancement of BMP signaling regulates hepcidin (HAMP) expression and iron metabolism (By similarity). May cooperate with hepcidin to restrict iron absorption in the gut. Could represent the cellular receptor for hepcidin |
| Tissue Specificity | Adult and fetal liver, heart, and skeletal muscle |
| Cellular Localization | Cell membrane; Lipid-anchor, GPI-anchor (By similarity) |
| Entrez Gene | 148738 |
|---|
Application
Western blot analysis of HFE2 Antibody (Center) in mouse heart tissue lysates (35ug/lane). HFE2 (arrow) was detected using the purified Pab.
Application
HFE2 Antibody (Center) IHC analysis in formalin fixed and paraffin embedded skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the HFE2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
