Application
HLA-DMB Antibody (Center) western blot analysis in Ramos cell line lysates (35ug/lane).This demonstrates the HLA-DMB antibody detected the HLA-DMB protein (arrow).| Product Name | HLA-DMB Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | DMB, RING7 |
|---|---|
| Alternative Names | HLA-DMB DMB RING7 HLA class II histocompatibility antigen DM beta chain MHC class II antigen DMB Really interesting new gene 7 protein |
| Molecular Weight(MW) | 28943 Da |
| Function | Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO |
| Tissue Specificity | This HLA-DMB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-133 amino acids from the Central region of human HLA-DMB. |
| Cellular Localization | Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Localizes to late endocytic compartment. Associates with lysosome membranes |
| Entrez Gene | 3109 |
|---|---|
| Nucleotide Accession | NP_002109.1 |
Application
HLA-DMB Antibody (Center) western blot analysis in Ramos cell line lysates (35ug/lane).This demonstrates the HLA-DMB antibody detected the HLA-DMB protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
