Application
HM13 Antibody (C-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the HM13 antibody detected the HM13 protein (arrow).| Product Name | HM13 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | H13, IMP1, PSL3, SPP |
|---|---|
| Alternative Names | HM13 H13 IMP1 PSL3 SPP Minor histocompatibility antigen H13 Intramembrane protease 1 Presenilin-like protein 3 Signal peptide peptidase |
| Molecular Weight(MW) | 41488 Da |
| Function | Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May play a role in graft rejection (By similarity). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1 |
| Tissue Specificity | Widely expressed with highest levels in kidney, liver, placenta, lung, leukocytes and small intestine and reduced expression in heart and skeletal muscle. Expressed abundantly in the CNS with highest levels in thalamus and medulla |
| Cellular Localization | Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity) |
| Entrez Gene | 81502 |
|---|---|
| Nucleotide Accession | NP_110416.1 NP_848697.1 |
Application
HM13 Antibody (C-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the HM13 antibody detected the HM13 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
