Application
HORMAD1 Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the HORMAD1 antibody detected the HORMAD1 protein (arrow).| Product Name | HORMAD1 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | HORMAD1; NOHMA; HORMA domain-containing protein 1; Cancer/testis antigen 46; Newborn ovary HORMA protein |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | NOHMA |
|---|---|
| Alternative Names | HORMAD1 NOHMA HORMA domain-containing protein 1 Cancer/testis antigen 46 Newborn ovary HORMA protein |
| Molecular Weight(MW) | 45200 Da |
| Function | Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes (By similarity) |
| Tissue Specificity | Testis-specific. Over-expressed in carcinomas. |
| Cellular Localization | Nucleus (By similarity). Chromosome (By similarity). Note=Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes. The expression of the phosphorylated form at Ser-377 is restricted to unsynapsed chromosomal regions (By similarity) |
| Entrez Gene | 84072 |
|---|---|
| Nucleotide Accession | NP_115508.2 |
Application
HORMAD1 Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the HORMAD1 antibody detected the HORMAD1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
