Application
Western blot analysis of HSD17B11 Antibody (N-term) in WiDr cell line lysates (35ug/lane). HSD17B11 (arrow) was detected using the purified Pab.Application
HSD17B11 Antibody (N-term) IHC analysis in formalin fixed and paraffin embedded lung tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the HSD17B11 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | HSD17B11 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | HSD17B11; DHRS8; PAN1B; Estradiol 17-beta-dehydrogenase 11; 17-beta-hydroxysteroid dehydrogenase 11; 17-beta-hydroxysteroid dehydrogenase XI; Cutaneous T-cell lymphoma-associated antigen HD-CL-03; Dehydrogenase/reductase SDR family member 8; Retinal short- |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | DHRS8 PAN1B |
|---|---|
| Alternative Names | HSD17B11 DHRS8 PAN1B Estradiol 17-beta-dehydrogenase 11 17-beta-hydroxysteroid dehydrogenase 11 17-beta-hydroxysteroid dehydrogenase XI Cutaneous T-cell lymphoma-associated antigen HD-CL-03 Dehydrogenase/reductase SDR family member 8 Retinal short- |
| Molecular Weight(MW) | 32936 Da |
| Function | Can convert androstan-3-alpha,17-beta-diol (3-alpha- diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor- associated antigen in cutaneous T-cell lymphoma |
| Tissue Specificity | Present at high level in steroidogenic cells such as syncytiotrophoblasts, sebaceous gland, Leydig cells, and granulosa cells of the dominant follicle and corpus luteum. In lung, it is detected in the ciliated epithelium and in acini of adult trachea, in bronchioles, but not in alveoli. In the eye, it is detected in the nonpigmented epithelium of the ciliary body and, at lower level, in the inner nuclear layer of the retina (at protein level). Widely expressed. Highly expressed in retina, pancreas, kidney, liver, lung, adrenal, small intestine, ovary and heart |
| Cellular Localization | Secreted (Potential). |
| Entrez Gene | 51170 |
|---|
Application
Western blot analysis of HSD17B11 Antibody (N-term) in WiDr cell line lysates (35ug/lane). HSD17B11 (arrow) was detected using the purified Pab.
Application
HSD17B11 Antibody (N-term) IHC analysis in formalin fixed and paraffin embedded lung tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the HSD17B11 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
