Application
HTATIP2 Antibody (N-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the HTATIP2 antibody detected the HTATIP2 protein (arrow).Application
HTATIP2 Antibody (N-term) (AP14762a)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of HTATIP2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | HTATIP2 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | HTATIP2; CC3; TIP30; Oxidoreductase HTATIP2; 30 kDa HIV-1 TAT-interacting protein; HIV-1 TAT-interactive protein 2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CC3 TIP30 |
|---|---|
| Alternative Names | HTATIP2 CC3 TIP30 Oxidoreductase HTATIP2 30 kDa HIV-1 TAT-interacting protein HIV-1 TAT-interactive protein 2 |
| Molecular Weight(MW) | 27049 Da |
| Function | Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties Isoform 2 has an antiapoptotic effect |
| Tissue Specificity | Ubiquitous. Highest level in liver. High levels in lung, skeletal muscle, pancreas and placenta. Moderate levels in heart and kidney. Low levels in brain. Not expressed or low levels in variant small cell lung carcinomas, 33% of hepatocellular carcinomas and neuroblastomas |
| Cellular Localization | Cytoplasm. Nucleus envelope. |
| Entrez Gene | 10553 |
|---|---|
| Nucleotide Accession | NP_001091991.1 NP_001091993.1 NP_001091992.1 |
Application
HTATIP2 Antibody (N-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the HTATIP2 antibody detected the HTATIP2 protein (arrow).
Application
HTATIP2 Antibody (N-term) (AP14762a)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of HTATIP2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
