Application
HTRA3 Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the HTRA3 antibody detected the HTRA3 protein (arrow).Application
HTRA3 Antibody (Center) (AP13989c)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of HTRA3 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | HTRA3 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | HTRA3; PRSP; Serine protease HTRA3; High-temperature requirement factor A3; Pregnancy-related serine protease |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | PRSP |
|---|---|
| Alternative Names | HTRA3 PRSP Serine protease HTRA3 High-temperature requirement factor A3 Pregnancy-related serine protease |
| Molecular Weight(MW) | 48608 Da |
| Function | Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization |
| Tissue Specificity | Widely expressed, with highest levels in both adult and fetal heart, ovary, uterus placenta, and bladder. In the endometrium, expressed in epithelial glands and the stroma. Also present in leukocytes. Isoform 1 is predominant in heart and skeletal muscle, whereas isoform 2 is predominant in placenta and kidney |
| Cellular Localization | Secreted. Note=Secretion increased during decidualization of endometrial stromal cells |
| Entrez Gene | 94031 |
|---|---|
| Nucleotide Accession | NP_444272.1 |
Application
HTRA3 Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the HTRA3 antibody detected the HTRA3 protein (arrow).
Application
HTRA3 Antibody (Center) (AP13989c)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of HTRA3 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
