Application
IFITM1 Antibody (Center) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the IFITM1 antibody detected the IFITM1 protein (arrow).| Product Name | IFITM1 (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | IFITM1; CD225; IFI17; Interferon-induced transmembrane protein 1; Dispanin subfamily A member 2a; Interferon-induced protein 17; Interferon-inducible protein 9-27; Leu-13 antigen; CD_antigen=CD225 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CD225 IFI17 |
|---|---|
| Alternative Names | IFITM1 CD225 IFI17 Interferon-induced transmembrane protein 1 Dispanin subfamily A member 2a Interferon-induced protein 17 Interferon-inducible protein 9-27 Leu-13 antigen CD_antigen=CD225 |
| Molecular Weight(MW) | 13964 Da |
| Function | IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein- mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation |
| Tissue Specificity | Bone (at protein level). Levels greatly elevated in colon cancer, cervical cancer, esophageal cancer and ovarian cancer. Expressed in glioma cell lines |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. |
| Entrez Gene | 8519 |
|---|---|
| Nucleotide Accession | NP_003632.3 |
Application
IFITM1 Antibody (Center) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the IFITM1 antibody detected the IFITM1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
