Application
IGSF8 Antibody (Center) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the IGSF8 antibody detected the IGSF8 protein (arrow).Application
IGSF8 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of IGSF8 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | IGSF8 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | IGSF8; CD81P3; EWI2; KCT4; Immunoglobulin superfamily member 8; CD81 partner 3; Glu-Trp-Ile EWI motif-containing protein 2; Keratinocytes-associated transmembrane protein 4; LIR-D1; Prostaglandin regulatory-like protein; CD_antigen=CD316; Flags: Precursor |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CD81P3 EWI2 KCT4 |
|---|---|
| Alternative Names | IGSF8 CD81P3 EWI2 KCT4 Immunoglobulin superfamily member 8 CD81 partner 3 Glu-Trp-Ile EWI motif-containing protein 2 Keratinocytes-associated transmembrane protein 4 LIR-D1 Prostaglandin regulatory-like protein CD_antigen=CD316 Flags: Precursor |
| Molecular Weight(MW) | 65034 Da |
| Function | May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin- dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain |
| Tissue Specificity | Expressed in brain, kidney, testis, liver and placenta with moderate expression in all other tissues. Detected on a majority of B-cells, T-cells, and natural killer cells but not on monocytes, polynuclear cells and platelets |
| Cellular Localization | Cell membrane (By similarity); Single-pass membrane protein |
| Entrez Gene | 93185 |
|---|---|
| Nucleotide Accession | NP_443100.1 |
Application
IGSF8 Antibody (Center) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the IGSF8 antibody detected the IGSF8 protein (arrow).
Application
IGSF8 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of IGSF8 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
