Application
Western blot analysis of IL17RD Antibody (N-term) in MDA-MB231 cell line lysates (35ug/lane). IL17RD (arrow) was detected using the purified Pab.| Product Name | IL17RD Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | IL17RD; IL17RLM; SEF; Interleukin-17 receptor D; IL17Rhom; Interleukin-17 receptor-like protein; Sef homolog |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | IL17RLM SEF |
|---|---|
| Alternative Names | IL17RD IL17RLM SEF Interleukin-17 receptor D IL17Rhom Interleukin-17 receptor-like protein Sef homolog |
| Molecular Weight(MW) | 82411 Da |
| Function | Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis |
| Tissue Specificity | Expressed in umbilical vein endothelial cells and in several highly vascularized tissues such as kidney, colon, skeletal muscle, heart and small intestine. Highly expressed in ductal epithelial cells of salivary glands, seminal vesicles and the collecting tubules of the kidney. Isoform 1 is also highly expressed in both fetal and adult brain, pituitary, tonsils, spleen, adenoids, fetal kidney, liver, testes and ovary. Isoform 1 is also expressed at moderate levels in primary aortic endothelial cells and adrenal medulla, and at low levels in adrenal cortex Isoform 4 is specifically and highly expressed in pituitary, fetal brain and umbilical vein endothelial cells |
| Cellular Localization | Golgi apparatus membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Note=Predominantly associated with the Golgi apparatus and is partially translocated to the plasma membrane upon stimulation |
Application
Western blot analysis of IL17RD Antibody (N-term) in MDA-MB231 cell line lysates (35ug/lane). IL17RD (arrow) was detected using the purified Pab.| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
