Application
IL22RA1 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the IL22RA1 antibody detected the IL22RA1 protein (arrow).| Product Name | IL22RA1 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | IL22RA1; IL22R; Interleukin-22 receptor subunit alpha-1; Cytokine receptor class-II member 9; Cytokine receptor family 2 member 9; ZcytoR11 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | IL22R |
|---|---|
| Alternative Names | IL22RA1 IL22R Interleukin-22 receptor subunit alpha-1 Cytokine receptor class-II member 9 Cytokine receptor family 2 member 9 ZcytoR11 |
| Molecular Weight(MW) | 63077 Da |
| Function | Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation |
| Tissue Specificity | Expressed in colon, liver, lung, pancreas and kidney. No expression in immune cells such as monocytes, T-cells, and NK-cells. Expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Detected in normal blood brain barrier endothelial cells as well as in multiple sclerosis lesions; Strongly expressed on central nervous system vessels within infiltrated multiple sclerosis lesions. Overexpressed in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients |
| Cellular Localization | Membrane; Single-pass type I membrane protein |
| Entrez Gene | 58985 |
|---|---|
| Nucleotide Accession | NP_067081.2 |
Application
IL22RA1 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the IL22RA1 antibody detected the IL22RA1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
