Application
ING2 Antibody (Center) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the ING2 antibody detected the ING2 protein (arrow).| Product Name | ING2 (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ING2; ING1L; Inhibitor of growth protein 2; Inhibitor of growth 1-like protein; p32; p33ING2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | ING1L |
|---|---|
| Alternative Names | ING2 ING1L Inhibitor of growth protein 2 Inhibitor of growth 1-like protein p32 p33ING2 |
| Molecular Weight(MW) | 32808 Da |
| Function | Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs) |
| Tissue Specificity | Widely expressed. Higher expressed in colon- cancer tumor than in normal colon tissues |
| Cellular Localization | Nucleus. Note=Predominantly nuclear. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm |
| Entrez Gene | 3622 |
|---|---|
| Nucleotide Accession | NP_001555.1 |
Application
ING2 Antibody (Center) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the ING2 antibody detected the ING2 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
