Application
IPO13 Antibody (C-term) western blot analysis in mouse testis tissue lysates (15ug/lane).This demonstrates the IPO13 antibody detected IPO13 protein (arrow).Application
IPO13 antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the IPO13 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | IPO13 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | IPO13; KIAA0724; RANBP13; Importin-13; Karyopherin-13; Ran-binding protein 13 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA0724 RANBP13 |
|---|---|
| Alternative Names | IPO13 KIAA0724 RANBP13 Importin-13 Karyopherin-13 Ran-binding protein 13 |
| Molecular Weight(MW) | 108195 Da |
| Function | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13 |
| Tissue Specificity | Expressed in fetal brain, heart, intestine and kidney |
| Cellular Localization | Cytoplasm. Nucleus. |
| Entrez Gene | 9670 |
|---|---|
| Nucleotide Accession | NP_055467.3 |
Application
IPO13 Antibody (C-term) western blot analysis in mouse testis tissue lysates (15ug/lane).This demonstrates the IPO13 antibody detected IPO13 protein (arrow).
Application
IPO13 antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the IPO13 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
