Application
A. Western blot analysis on 293 cell lysate using anti-IRS-4 RabMAb (Cat. #AJ1419a), dilution 1:5000.Application
B. Immunohistochemical staining of paraffin-embedded human kidney using anti-IRS-4 RabMAb (Cat. #AJ1419a).| Product Name | IRS-4 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | KCNJ11, ATP-sensitive inward rectifier potassium channel 11, Potassium channel, inwardly rectifying subfamily J member 11;Inward rectifier K(+) channel Kir6.2;IKATP |
| Clonality | Monoclonal |
|---|---|
| Clone Number | EP907Y |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:1000~10000 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | KCNJ11 ATP-sensitive inward rectifier potassium channel 11 Potassium channel inwardly rectifying subfamily J member 11 Inward rectifier K(+) channel Kir6.2 IKATP |
|---|---|
| Molecular Weight(MW) | 43541 Da |
| Function | This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation |
| Tissue Specificity | A synthetic peptide corresponding to residues on the C-terminus of human IRS-4 was used as an immunogen. |
| Cellular Localization | Membrane; Multi-pass membrane protein. |
| Entrez Gene | 3767 |
|---|
Application
A. Western blot analysis on 293 cell lysate using anti-IRS-4 RabMAb (Cat. #AJ1419a), dilution 1:5000.
Application
B. Immunohistochemical staining of paraffin-embedded human kidney using anti-IRS-4 RabMAb (Cat. #AJ1419a).| Application Notes | WB:1:1000~10000 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
