Application
ITGB7 Antibody (C-term) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the ITGB7 antibody detected the ITGB7 protein (arrow).| Product Name | ITGB7 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ITGB7; Integrin beta-7; Gut homing receptor beta subunit |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | ITGB7 Integrin beta-7 Gut homing receptor beta subunit |
|---|---|
| Molecular Weight(MW) | 86903 Da |
| Function | Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT) Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin |
| Tissue Specificity | Expressed in a variety of leukocyte lines. |
| Cellular Localization | Membrane; Single-pass type I membrane protein |
| Entrez Gene | 3695 |
|---|---|
| Nucleotide Accession | NP_000880.1 |
Application
ITGB7 Antibody (C-term) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the ITGB7 antibody detected the ITGB7 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
