Application
ITM2C Antibody (N-term) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the ITM2C antibody detected the ITM2C protein (arrow).| Product Name | ITM2C Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ITM2C; BRI3; Integral membrane protein 2C; Cerebral protein 14; Transmembrane protein BRI3; CT-BRI3 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | BRI3 |
|---|---|
| Alternative Names | ITM2C BRI3 Integral membrane protein 2C Cerebral protein 14 Transmembrane protein BRI3 CT-BRI3 |
| Molecular Weight(MW) | 30224 Da |
| Function | Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C- terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity) |
| Tissue Specificity | High levels in the brain, specifically in the cerebral cortex, medulla, amygdala, hippocampus, thalamus, caudate nucleus, cerebellum, olfactory lobe and spinal cord. Very low levels in other organs |
| Cellular Localization | Lysosome membrane; Single-pass type II membrane protein (By similarity). Cell membrane; Single-pass type II membrane protein |
| Entrez Gene | 81618 |
|---|---|
| Nucleotide Accession | NP_001012532.1 NP_001012534.1 |
Application
ITM2C Antibody (N-term) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the ITM2C antibody detected the ITM2C protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
