Application
ITM2B Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ITM2B Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.Application
ITM2B Antibody (C-term) western blot analysis in mouse cerebellum,lung tissue lysates (35ug/lane).This demonstrates the ITM2B antibody detected the ITM2B protein (arrow).| Product Name | ITM2B Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ITM2B; BRI; BRI2; Integral membrane protein 2B; Immature BRI2; Protein E25B; Transmembrane protein BRI; BRI2, membrane form; Mature BRI2; BRI2 intracellular domain; BRI2C, soluble form; Bri23 peptide; ABri23; C-terminal peptide; P23 peptide |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| IHC:1:10~50 WB |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | BRI BRI2 |
|---|---|
| Alternative Names | ITM2B BRI BRI2 Integral membrane protein 2B Immature BRI2 Protein E25B Transmembrane protein BRI BRI2 membrane form Mature BRI2 BRI2 intracellular domain BRI2C soluble form Bri23 peptide ABri23 C-terminal peptide P23 peptide |
| Molecular Weight(MW) | 30338 Da |
| Function | Plays a regulatory role in the processing of the beta- amyloid A4 precursor protein (APP) and acts as an inhibitor of the beta-amyloid peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites Bri23 peptide prevents aggregation of APP beta-amyloid protein 42 peptide into toxic oligomers |
| Tissue Specificity | Ubiquitous. Expressed in brain. |
| Cellular Localization | Integral membrane protein 2B: Golgi apparatus membrane; Single-pass type II membrane protein Note=Immature BRI2 (imBRI2) is cleaved by furin in the Golgi into mBRI2 and a Bri23 peptide. mBRI2 is transported to the plasma membrane and Bri23 peptide is secreted Bri23 peptide: Secreted. Note=Detected in the cerebral spinal fluid (CSF) |
| Entrez Gene | 9445 |
|---|---|
| Nucleotide Accession | NP_068839.1 |
Application
ITM2B Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ITM2B Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Application
ITM2B Antibody (C-term) western blot analysis in mouse cerebellum,lung tissue lysates (35ug/lane).This demonstrates the ITM2B antibody detected the ITM2B protein (arrow).| Application Notes | IHC:1:10~50 WB |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
