Application
JARID1B Antibody (N-term) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the JARID1B antibody detected the JARID1B protein (arrow).| Product Name | JARID1B Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | KDM5B; JARID1B; PLU1; RBBP2H1; Lysine-specific demethylase 5B; Cancer/testis antigen 31; Histone demethylase JARID1B; Jumonji/ARID domain-containing protein 1B; PLU-1; Retinoblastoma-binding protein 2 homolog 1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | JARID1B PLU1 RBBP2H1 |
|---|---|
| Alternative Names | KDM5B JARID1B PLU1 RBBP2H1 Lysine-specific demethylase 5B Cancer/testis antigen 31 Histone demethylase JARID1B Jumonji/ARID domain-containing protein 1B PLU-1 Retinoblastoma-binding protein 2 homolog 1 |
| Molecular Weight(MW) | 175658 Da |
| Function | Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma |
| Tissue Specificity | Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer (at protein level) |
| Cellular Localization | Nucleus. |
| Entrez Gene | 10765 |
|---|---|
| Nucleotide Accession | NP_006609.3 |
Application
JARID1B Antibody (N-term) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the JARID1B antibody detected the JARID1B protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
