Application
Western blot analysis of K0406 Antibody (N-term) in K562 cell line lysates (35ug/lane). K0406 (arrow) was detected using the purified Pab.| Product Name | K0406 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TTI1; KIAA0406; SMG10; TELO2-interacting protein 1 homolog; Protein SMG10 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA0406 SMG10 |
|---|---|
| Alternative Names | TTI1 KIAA0406 SMG10 TELO2-interacting protein 1 homolog Protein SMG10 |
| Molecular Weight(MW) | 122069 Da |
| Function | Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals |
| Tissue Specificity | Widely expressed. |
| Cellular Localization | Cytoplasm. |
Application
Western blot analysis of K0406 Antibody (N-term) in K562 cell line lysates (35ug/lane). K0406 (arrow) was detected using the purified Pab.| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
