Application
KLK7 Antibody (S82) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the KLK7 antibody detected the KLK7 protein (arrow).Application
Kallikrein 7(KLK7) Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human skin tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Kallikrein 7(KLK7) Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | Kallikrein 7 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | KLK7; PRSS6; SCCE; Kallikrein-7; Serine protease 6; Stratum corneum chymotryptic enzyme |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | PRSS6 SCCE |
|---|---|
| Alternative Names | KLK7 PRSS6 SCCE Kallikrein-7 Serine protease 6 Stratum corneum chymotryptic enzyme |
| Molecular Weight(MW) | 27525 Da |
| Function | May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines |
| Tissue Specificity | Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at protein level) |
| Cellular Localization | Secreted. Note=In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front |
| Entrez Gene | 5650 |
|---|
Application
KLK7 Antibody (S82) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the KLK7 antibody detected the KLK7 protein (arrow).
Application
Kallikrein 7(KLK7) Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human skin tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Kallikrein 7(KLK7) Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
