Application
KCNJ6 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the KCNJ6 antibody detected the KCNJ6 protein (arrow).Application
KCNJ6 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the KCNJ6 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.Application
KCNJ6 Antibody (Center) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.| Product Name | KCNJ6 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | KCNJ6; GIRK2; KATP2; KCNJ7; G protein-activated inward rectifier potassium channel 2; BIR1; Inward rectifier K(+) channel Kir3.2; KATP-2; Potassium channel, inwardly rectifying subfamily J member 6 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHCFC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | GIRK2 KATP2 KCNJ7 |
|---|---|
| Alternative Names | KCNJ6 GIRK2 KATP2 KCNJ7 G protein-activated inward rectifier potassium channel 2 BIR1 Inward rectifier K(+) channel Kir3.2 KATP-2 Potassium channel inwardly rectifying subfamily J member 6 |
| Molecular Weight(MW) | 48451 Da |
| Function | This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium |
| Tissue Specificity | Most abundant in cerebellum, and to a lesser degree in islets and exocrine pancreas |
| Cellular Localization | Membrane; Multi-pass membrane protein. |
| Entrez Gene | 3763 |
|---|---|
| Nucleotide Accession | NP_002231.1 |
Application
KCNJ6 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the KCNJ6 antibody detected the KCNJ6 protein (arrow).
Application
KCNJ6 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the KCNJ6 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Application
KCNJ6 Antibody (Center) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
