Application
KCNK18 Antibody (Center) western blot analysis in SiHa,U251,MCF-7 cell line lysates (35ug/lane).This demonstrates the KCNK18 antibody detected the KCNK18 protein (arrow).Application
KCNK18 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of KCNK18 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | KCNK18 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | KCNK18; TRESK; TRIK; Potassium channel subfamily K member 18; TWIK-related individual potassium channel; TWIK-related spinal cord potassium channel |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | TRESK TRIK |
|---|---|
| Alternative Names | KCNK18 TRESK TRIK Potassium channel subfamily K member 18 TWIK-related individual potassium channel TWIK-related spinal cord potassium channel |
| Molecular Weight(MW) | 43671 Da |
| Function | Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation (By similarity) |
| Tissue Specificity | Expressed specifically in dorsal root ganglion and trigeminal ganglion neurons. Detected at low levels in spinal cord |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. |
| Entrez Gene | 338567 |
|---|---|
| Nucleotide Accession | NP_862823.1 |
Application
KCNK18 Antibody (Center) western blot analysis in SiHa,U251,MCF-7 cell line lysates (35ug/lane).This demonstrates the KCNK18 antibody detected the KCNK18 protein (arrow).
Application
KCNK18 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of KCNK18 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
