Application
KCNMB1 Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the KCNMB1 antibody detected the KCNMB1 protein (arrow).| Product Name | KCNMB1 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | KCNMB1; Calcium-activated potassium channel subunit beta-1; BK channel subunit beta-1; Calcium-activated potassium channel, subfamily M subunit beta-1; Charybdotoxin receptor subunit beta-1; K(VCA)beta-1; Maxi K channel subunit beta-1; Slo-beta-1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | KCNMB1 Calcium-activated potassium channel subunit beta-1 BK channel subunit beta-1 Calcium-activated potassium channel subfamily M subunit beta-1 Charybdotoxin receptor subunit beta-1 K(VCA)beta-1 Maxi K channel subunit beta-1 Slo-beta-1 |
|---|---|
| Molecular Weight(MW) | 21797 Da |
| Function | Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate |
| Tissue Specificity | Abundantly expressed in smooth muscle. Low levels of expression in most other tissues. Within the brain, relatively high levels found in hippocampus and corpus callosum |
| Cellular Localization | Membrane; Multi-pass membrane protein. |
| Entrez Gene | 3779 |
|---|---|
| Nucleotide Accession | NP_004128.1 |
Application
KCNMB1 Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the KCNMB1 antibody detected the KCNMB1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
