Application
KIAA1530 Antibody (N-term) western blot analysis in Y79 cell line lysates (35ug/lane).This demonstrates the KIAA1530 antibody detected the KIAA1530 protein (arrow).| Product Name | KIAA1530 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | UVSSA; KIAA1530; UV-stimulated scaffold protein A |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA1530 |
|---|---|
| Alternative Names | UVSSA KIAA1530 UV-stimulated scaffold protein A |
| Molecular Weight(MW) | 80591 Da |
| Function | Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage |
| Tissue Specificity | This KIAA1530 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 159-189 amino acids from the N-terminal region of human KIAA1530. |
| Cellular Localization | Chromosome. Note=Accumulates at UV DNA damage sites |
| Entrez Gene | 57654 |
|---|---|
| Nucleotide Accession | NP_065945.2 |
Application
KIAA1530 Antibody (N-term) western blot analysis in Y79 cell line lysates (35ug/lane).This demonstrates the KIAA1530 antibody detected the KIAA1530 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
