Application
KIAA1967 Antibody (N-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the KIAA1967 antibody detected the KIAA1967 protein (arrow).| Product Name | KIAA1967 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | KIAA1967; DBC1; DBIRD complex subunit KIAA1967; Deleted in breast cancer gene 1 protein; p30 DBC |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | DBC1 |
|---|---|
| Alternative Names | KIAA1967 DBC1 DBIRD complex subunit KIAA1967 Deleted in breast cancer gene 1 protein p30 DBC |
| Molecular Weight(MW) | 102902 Da |
| Function | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity |
| Tissue Specificity | Expressed ubiquitously in normal tissues. Expressed in 84 to 100% of neoplastic breast, lung, and colon tissues |
| Cellular Localization | Nucleus (Probable). |
| Entrez Gene | 57805 |
|---|---|
| Nucleotide Accession | NP_066997.3 |
Application
KIAA1967 Antibody (N-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the KIAA1967 antibody detected the KIAA1967 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
