Application
KIF2C Antibody (N-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the KIF2C antibody detected the KIF2C protein (arrow).| Product Name | KIF2C Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | KIF2C; KNSL6; Kinesin-like protein KIF2C; Kinesin-like protein 6; Mitotic centromere-associated kinesin |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KNSL6 |
|---|---|
| Alternative Names | KIF2C KNSL6 Kinesin-like protein KIF2C Kinesin-like protein 6 Mitotic centromere-associated kinesin |
| Molecular Weight(MW) | 81313 Da |
| Function | In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis |
| Tissue Specificity | Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal lining of colon, and placenta, and at very low levels in spleen and ovary; expression is not detected in prostate, peripheral blood Leukocytes, heart, brain, lung, liver, skeletal muscle, kidney or pancreas. Isoform 2 is testis-specific |
| Cellular Localization | Cytoplasm, cytoskeleton (By similarity). Nucleus (By similarity). Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity). Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGOL2 |
| Entrez Gene | 11004 |
|---|---|
| Nucleotide Accession | NP_006836.2 |
Application
KIF2C Antibody (N-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the KIF2C antibody detected the KIF2C protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
