Application
KISS1R Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the KISS1R antibody detected the KISS1R protein (arrow).| Product Name | KISS1R Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | KISS1R;AXOR12; GPR54; KiSS-1 receptor; KiSS-1 receptor; G-protein coupled receptor 54; KiSS-1 receptor; G-protein coupled receptor OT7T175; KiSS-1 receptor; Hypogonadotropin-1; KiSS-1 receptor; Kisspeptins receptor; KiSS-1 receptor; Metastin receptor |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | AXOR12 GPR54 |
|---|---|
| Alternative Names | KISS1R AXOR12 GPR54 KiSS-1 receptor KiSS-1 receptor G-protein coupled receptor 54 KiSS-1 receptor G-protein coupled receptor OT7T175 KiSS-1 receptor Hypogonadotropin-1 KiSS-1 receptor Kisspeptins receptor KiSS-1 receptor Metastin receptor |
| Molecular Weight(MW) | 42586 Da |
| Function | Receptor for metastin (kisspeptin-54 or kp-54), a C- terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood The receptor is also probably involved in the regulation and fine- tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins |
| Tissue Specificity | Most highly expressed in the pancreas, placenta and spinal cord, with lower-level of expression in peripheral blood leukocytes, kidney, lung, fetal liver, stomach, small intestine, testes, spleen, thymus, adrenal glands and lymph nodes. In the adult brain, expressed in the superior frontal gyrus, putamen, caudate nucleus, cingulate gyrus, nucleus accumbens, hippocampus, pons and amygdala, as well as the hypothalamus and pituitary. Expression levels are higher in early (7-9 weeks) than term placentas. Expression levels were increased in both early placentas and molar pregnancies and were reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation. Also found in the extravillous trophoblast suggesting endocrine/paracrine activation mechanism |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. |
| Entrez Gene | 84634 |
|---|
Application
KISS1R Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the KISS1R antibody detected the KISS1R protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
